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August 1978

Oral Methoxsalen Photochemotherapy for Acne Vulgaris

Arch Dermatol. 1978;114(8):1241-1242. doi:10.1001/archderm.1978.01640200089032

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To the Editor.—  Seven volunteer patients with moderate to severe (grades II through IV) pustular or cystic acne of the face, chest, and back were selected for treatment with oral methoxsalen photochemotherapy. Patients with mild comedonal acne were not accepted for the study. Those patients who had been taking tetracycline or female hormones for more than three or four months, respectively, prior to the initial evaluation were included in the study, and their drug dosage was held constant. Those taking these drugs for shorter periods of time were not included. All patients selected for the study agreed to avoid intentional sun exposure of the trunk and face until the study had been completed. Patients were photographed and their conditions were evaluated by the same investigator before therapy began and after therapy was discontinued. Lesion counts were performed on each visit.A bilateral comparison technique was used for all patients. The

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