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Article
August 1978

Circulating Antibodies Reactive With Cytoplasmic Antigens of Upper and Germinal Cells of Human Skin-Reply

Arch Dermatol. 1978;114(8):1246. doi:10.1001/archderm.1978.01640200093048

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Abstract

In Reply.—  It is interesting to learn that the immunofluorescent staining pattern of sera reacting to cytoplasmic antigens can change as a result of prozone phenomenon when the sera are examined at low dilutions. We did not encounter this problem in any of the sera we screened, though none were tested at dilutions below 1:40.It is gratifying to see that the additional data on the incidence of basal cell antibodies presented by Van Joost confirms that they are uncommon and that, while their presence is associated with immune disorders involving the skin, they are not associated with any one particular disease.

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