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Article
September 1978

The Use of Levamisole in Atopic DermatitisA Prospective Study

Author Affiliations

From the Department of Dermatology, Hospital de San Pablo, Autonomous University of Barcelona, Spain.

Arch Dermatol. 1978;114(9):1316-1319. doi:10.1001/archderm.1978.01640210011003
Abstract

• Levamisole hydrochloride, a nonspecific immunostimulant, was given to 30 children with atopic dermatitis (AD) in a double-blind manner during an eightmonth period. Clinical course findings, including intradermal reactions to tuberculin, candidin, and streptokinase-streptodornase; sensitization to dinitrochlorobenzene; peripheral blood T- and Blymphocytes; in vitro lymphocyte transformation with phytohemagglutinin; and serum levels of IgM, IgG, IgA, and IgE, were noted every two months. Fifteen children completed the study. Neither the clinical course nor the immunologic values showed substantial differences between the levamisole-treated and the placebo group. Our experience with levamisole in AD is disappointing.

(Arch Dermatol 114:1316-1319, 1978)

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