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Article
September 1978

Darier's DiseaseAn Immunologic Study

Author Affiliations

From the Dermatology (Dr Marks) and Allergy and Immunology (Dr Lowe) Services, Wilford Hall USAF Medical Center, Lackland AFB, Tex, and the Departments of Microbiology and Pathology, University of Texas Health Science Center (Dr Thor), San Antonio, Tex.

Arch Dermatol. 1978;114(9):1336-1339. doi:10.1001/archderm.1978.01640210031008
Abstract

• Darier's disease is frequently complicated by bacterial skin infections and occasionally by Kaposi's varicelliform eruption. Postulating that defective host immunologic competence might explain these infections, humoral and cell-mediated immunity (CMI) were evaluated in four patients. Humoral immunity was normal as demonstrated by quantitative immunoglobulins, isohemagglutinins, direct skin immunofluorescence, and B-cell counts. The CMI was evaluated by standard delayed type hypersensitivity skin tests, T-cell counts, lymphocyte transformation assays, macrophage inhibition factor (MIF) assays, and skin windows. Blunted lymphocyte blastogenesis, MIF, and skin window response indicated depressed CMI. Polymorphonuclear leukocyte chemotaxis and phagocytosis were normal.

(Arch Dermatol 114:1336-1339, 1978)

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