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October 1978

Anthracene With Near Ultraviolet Light Inhibiting Epidermal Proliferation

Author Affiliations

From the Division of Dermatology, University of California, San Diego, School of Medicine.

Arch Dermatol. 1978;114(10):1463-1465. doi:10.1001/archderm.1978.01640220012003

• Anthracene plus near ultraviolet (UV) light (UV-A, 320 to 400 nm) suppresses DNA synthesis and mitosis in mouse epidermis. Ultraviolet-A light or anthracene alone does not have any effect. There is no photoactivation of anthracene to enhance depression of DNA synthesis by either UV-B (290 to 320 nm) or UV-C (254 nm) light. While methoxsalen with UV-A light inhibits DNA synthesis, the phototoxic drugs chlorpromazine hydrochloride and demethylchlortetracycline do not. The combination of anthracene plus UV-A light may have therapeutic effectiveness for psoriasis with less potential for photocarcinogenesis than psoralens plus UV-A light.

(Arch Dermatol 114:1463-1465, 1978)