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Article
October 1978

The Genetics of Follicular Atrophoderma

Author Affiliations

From the Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York.

Arch Dermatol. 1978;114(10):1479-1483. doi:10.1001/archderm.1978.01640220028006
Abstract

• Follicular atrophoderma apparently does not occur alone but is associated with other abnormalities. It is present in three groups: (1) If it is associated with chondrodystrophia calcificans congenita, it occurs only in girls and is due either to an X-chromosomal gene causing the changes in the heterozygote (ie, in the female sex) and prenatal death in the hemizygous state (ie, in the male sex), or to an autosomal dominant gene with expression almost wholly limited to the female sex; (2) If it is associated with Bazex's syndrome, it occurs in male and female persons in successive generations and is due either to an autosomal dominant gene or to an X-linked dominant gene; and (3) If it occurs in association with keratosis palmoplantaris dissipata, keratosis follicularis, and hyperhidrosis palmoplantaris, it may be due to a recessive gene or a mutation.

(Arch Dermatol 114:1479-1483, 1978)

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