Lymphomatoid granulomatosis is a lymphoreticular proliferative disorder that involves the lungs, skin, and CNS.1,2 A case of skin eruption that underwent spontaneous resolution as pulmonary involvement appeared is reported.
Report of a Case
A 55-year-old man had a skin eruption for nine weeks that involved the face, trunk, and arms. The lesions were elevated, erythematous, and annular, with central clearing and hypesthesia. A skin biopsy specimen showed chronic granulomatous inflammation (Fig 1). He was receiving no medication on discharge.Fig 1.—Focal dermal periappendigeal and perivascular chronic inflammatory infiltrate (hematoxylin-eosin, ×5.45).Fig 2.—Consolidated lung, with centrally necrotic nodules.Fig 3.—Mixed infiltrate of chronic inflammatory cells with binucleate histiocytes (left, arrow) and mitoses (right) (hematoxylin-eosin, ×530).In two weeks he was readmitted with progressive dyspnea, tachycardia, and tachypnea. Arterial Pco2 was 32 mm Hg; Po3 was 47 mm Hg. Chest x-ray film showed bilateral patchy interstitial and nodular infiltrates. The
Bender BL, Kapadia SB, Synkowski DR, Zitelli JA. Lymphomatoid Granulomatosis Preceded by Chronic Granulomatous Dermatitis. Arch Dermatol. 1978;114(10):1547-1548. doi:10.1001/archderm.1978.01640220090027