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October 1978

Depigmenting Agents and Melanoma

Author Affiliations

San Mateo, Calif

Arch Dermatol. 1978;114(10):1551. doi:10.1001/archderm.1978.01640220092029

To the Editor.—  Drs Lerner and Nordlund asserted in their letter in the April issue of the Archives (114:628, 1978) that I had completely missed their point because they had intended to say that phenols and catechols should be used to destroy melanomas not by direct cytotoxic action, but by immunologic reaction. I guess I still completely miss their point because my results showed no vitiligo, no melanoma regression, and no prolongation of host survival following injections of phenols and catechols into early hamster melanomas. These were the results, irrespective of mechanisms proposed. It should be added that the hamster melanoma used seemed to be susceptible to immunologic attack, since regressions were achieved with intralesional injections of Corynebacterium (Propionitbacterium) granulosum.1

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