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To the Editor.—
Scherzer has commented on the development of numerous comedones in acne patients treated with a solution of 5% lincomycin hydrochloride monohydrate in 70% isopropyl alcohol and requests the observation of others (Archives 114:799,1978). I, too, have been using a topical 5% alcoholic lincomycin solution in selected acne patients with inflammatory acne for the past nine months, and have had excellent response. So far, these patients have not developed comedones while under therapy. However, I usually use the formula of Barranco et al (Archives 112:1469,1978), which incorporates the lincomycin in ethyl alcohol, not isopropyl alcohol. In addition, my patients receiving topical antibiotic therapy also receive topical tretinoin as an integral part of the regimen.
Lee BW. Topical 5% Alcoholic Lincomycin Solution for Treatment of Acne. Arch Dermatol. 1978;114(10):1551. doi:10.1001/archderm.1978.01640220092030