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December 1978

Iodochlorhydroxyquin-Hydrocortisone Treatment of Fungal InfectionsDouble-Blind Trial

Author Affiliations

From the University of California Medical School, San Francisco.

Arch Dermatol. 1978;114(12):1773-1775. doi:10.1001/archderm.1978.01640240015004

• A double-blind multicenter study compared the antifungal effectiveness of an iodochlorhydroxyquin-hydrocortisone cream with that of its individual components in 354 patients with cutaneous fungal infections. After seven days of treatment, the combination was considerably better than hydrocortisone or the cream vehicle with respect to erythema, scaling, itching, and patients' and physicians' evaluations. The proportion of patients in the iodochlorhydroxyquin-hydrocortisone and iodochlorhydroxyquin groups who changed from positive results on potassium hydroxide examination at baseline to negative results on potassium hydroxide examination after treatment was significantly greater than that in the hydrocortisone and placebo groups. The conversion rate associated with the iodochlorhydroxyquin-hydrocortisone and the iodochlorhydroxyquin treatments was significantly different from that associated with hydrocortisone alone or placebo treatment.

(Arch Dermatol 114:1773-1775, 1978)