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December 1978

Hyperimmunoglobulinemia E Syndrome

Author Affiliations

Genoa, Italy

Arch Dermatol. 1978;114(12):1854. doi:10.1001/archderm.1978.01640240078028

To the Editor.—  The article, "Clinical Syndrome of Chemotaxis Defect, Infections, and Hyperimmunoglobulinemia E" by Drs Wyre and Johnson, which appeared in the January 1978 Archives (114:74-77), is spotted with minor flaws that deserve some comments.First, as Drs Wyre and Johnson indicate, the lesions of the face look much more like severe acne than eczematous dermatitis as described by pediatricians; in fact, we have also found that the facial dermatitis of the hyperimmunoglobulinemia E syndrome is more pustular than eczematous. The authors do not stress this point at all, though it is of paramount importance for dermatologists.Furthermore, Drs Wyre and Johnson do not emphasize the presence (actually difficult to define in blacks) of the broad nasal bridge, which is claimed to be a common feature of this "not unusual" syndrome.The blood level of IgA is exceedingly high and should be discussed. This finding is particularly interesting since

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