The function of T cells in atopic dermatitis was studied by leukocyte migration agarose and lymphocyte transformation tests. We found that phytohemagglutinin (PHA)- and PPD-induced release of leukocyte migration inhibition factor (LIF) from lymphocytes is significantly decreased (P <.001) in patients with atopic dermatitis as compared with healthy controls. Blastogenic response of lymphocytes induced by PPD was also decreased in atopic patients as compared with controls (P <.01). No differences were found in spontaneous blastogenesis or in blastogenic response of lymphocytes in vitro to PHA, concanavalin A (ConA), or streptokinase-streptodornase (SK-SD) between patients with atopic dermatitis and controls.
(Arch Dermatol 115:161-164, 1979)
Horsmanheimo M, Horsmanheimo A, Banov CH, Ainsworth SK, Fudenberg HH. Cell-Mediated Immunity In Vitro in Atopic Dermatitis. Arch Dermatol. 1979;115(2):161-164. doi:10.1001/archderm.1979.04010020007003