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February 1979

Generalized Malignant Acanthosis Nigricans

Author Affiliations

From the Departments of Dermatology (Drs Mikhail and Fachnie), Obstetrics and Gynecology (Dr Drukker), Urology (Dr Farah), and General Surgery (Dr Allen), Henry Ford Hospital, Detroit.

Arch Dermatol. 1979;115(2):201-202. doi:10.1001/archderm.1979.04010020047014

We report a case of generalized malignant acanthosis nigricans (AN) secondary to metastasizing squamous cell carcinoma of the cervix uteri. The disease initially manifested in the perineum as condyloma acuminatum-like lesions. Subsequently, most of the cutaneous surface and the mucosa of the vulva, mouth, tongue, and the palpebral conjunctiva became involved. The association of AN with a squamous cell carcinoma is rare, and conjunctival involvement is unusual.

(Arch Dermatol 115:201-202, 1979)