We report a case of generalized malignant acanthosis nigricans (AN) secondary to metastasizing squamous cell carcinoma of the cervix uteri. The disease initially manifested in the perineum as condyloma acuminatum-like lesions. Subsequently, most of the cutaneous surface and the mucosa of the vulva, mouth, tongue, and the palpebral conjunctiva became involved. The association of AN with a squamous cell carcinoma is rare, and conjunctival involvement is unusual.
(Arch Dermatol 115:201-202, 1979)
Mikhail GR, Fachnie DM, Drukker BH, Farah R, Allen HM. Generalized Malignant Acanthosis Nigricans. Arch Dermatol. 1979;115(2):201-202. doi:10.1001/archderm.1979.04010020047014