Periumbilical pseudoxanthoma elasticum (PXE) with transepidermal elimination of altered elastica presented a distinctive clinical pattern in six middleaged, multiparous women. Other sites usually affected in PXE were spared. The possible genetic predisposition to PXE of these patients found its expression in the periumbilical skin, a site exposed to the trauma of multiple pregnancies. The extruded elastica had tinctorial properties that were characteristic of PXE. The clinical picture in our cases differs from classic PXE. A peculiar acquired cutaneous PXE is not excluded.
(Arch Dermatol 115:300-303, 1979)
Hicks J, Carpenter CL, Reed RJ. Periumbilical Perforating Pseudoxanthoma Elasticum. Arch Dermatol. 1979;115(3):300-303. doi:10.1001/archderm.1979.04010030008003