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Article
March 1979

Cutaneous T-Cell Lymphoma in Association With a Monoclonal Gammopathy

Author Affiliations

From the Department of Haematology, Clinique Medicale du Professeur Audoly, Hopital de Cimiez, Nice, France. Dr Joyner is presently with the Department of Haemotology, King's College Hospital, London.

Arch Dermatol. 1979;115(3):326-328. doi:10.1001/archderm.1979.04010030034013
Abstract

Monoclonal gammopathies and other abnormalities of immunoglobulin production may characterize or frequently be associated with B-cell lymphoproliferative disorders. We describe a patient with a T-cell cutaneous lymphoma, expressed clinically as Sézary's syndrome, in association with an immunoglobulin A type kappa M-component monoclonal gammopathy. No evidence for the coincident presence of a malignant plasma dyscrasia was found. This clinical association may lend clinical support to the concept that Sézary's syndrome is a T-helper-cell malignant proliferation. A colonic carcinoma was also present, possibly representing a second manifestation of a functionally abnormal cellular immune system.

(Arch Dermatol 115:326-328, 1979)

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