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April 1979

Alkaptonuria With Extensive Ochronosis

Author Affiliations


From the Department of Dermatology, Naval Regional Medical Center, Portsmouth, Va. Dr Wyre is now with the National Naval Medical Center and the Uniformed Services University of the Health Sciences, Bethesda, Md.

Arch Dermatol. 1979;115(4):461-463. doi:10.1001/archderm.1979.04010040039013

A 59-year-old woman with previously documented alkaptonuria was examined for extensive ochronosis of recent onset. The cause of the extensive skin pigmentations was thought to be secondary to decreased renal clearance of homogentisic acid because of a decline in the patient's renal function. If extensive or rapidly progressive skin pigmentation is noted in a patient with alkaptonuria, then evaluation of the patient's renal status should be done because unrelated renal disease has been reported in patients with severe ochronosis.

(Arch Dermatol 115:461-463, 1979)