A diabetic patient had delayed local cutaneous allergic reactions to insulin. We describe his lesion, biopsy findings, and treatment. Allergic reactions to insulin may be immediate local or systemic, which are IgE-mediated, or delayed local, which are IgG-mediated. Recommended management of local reactions is to use a single-peak pork insulin of the insulin zinc suspension series. Progressive immediate local reactions may herald the onset of systemic reactions. Hospitalization and desensitization to insulin may be required for systemic allergic reactions to insulin.
(Arch Dermatol 115:591-592, 1979)
Lynfield Y, Rosman P. Insulin AllergyReport of a Case With Delayed Local Reaction. Arch Dermatol. 1979;115(5):591-592. doi:10.1001/archderm.1979.04010050025010