Two cases of granulomatous dermatitis with eosinophilia (Wells' syndrome) are reported. With Wells' original four cases, these two cases define a distinctive dermatosis with onset as cellulitis and formation of solid edema and either final spontaneous resolution or resolution with steroid therapy. Microscopic study showed diffuse tissue eosinophilia and fibrinoid flame figures, evolution of associated focal necrobiosis, and formation of focal microgranulomas associated with eosinophils. Biopsy of muscle and fascia showed comparable fasciitis and eosinophilic myositis. Immunofluorescence in one case disclosed fibrin in the dermis and IgM, IgA, and C3 in the blood vessels of the muscle. Recurrences of the lesions often appeared to be related to drug administration or surgery.
(Arch Dermatol 115:611-613, 1979)
Spigel GT, Winkelmann RK. Wells' SyndromeRecurrent Granulomatous Dermatitis With Eosinophilia. Arch Dermatol. 1979;115(5):611-613. doi:10.1001/archderm.1979.04010050045016