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Article
May 1979

Generalized Connective Tissue Nevi and Ichthyosis in Down's Syndrome

Author Affiliations

From the Division of Dermatology, Affiliated Hospitals of Albert Einstein College of Medicine, Montefiore Hospital Medical Center; and Bronx Municipal Hospital Center.; Dr Levine is now with the University of Arizona Medical Center, Tucson.

Arch Dermatol. 1979;115(5):623-624. doi:10.1001/archderm.1979.04010050053019
Abstract

The first description of a localized connective tissue nevus with a decreased amount of elastic tissue is credited to Lewandowsky in 1921. Various authors designated these localized hamartomas as nevus anelasticus according to the histologic presentation of the nevus. Sachs1 reported a generalized process that developed after furunculosis and Loewenthal2 described a case in which the lesions became generalized over a ten-year period. We report a case of generalized connective tissue nevi with a decrease in elastic tissue in a patient with Down's syndrome.

Report of a Case  A 47-year-old man who had Down's syndrome was admitted to Bronx Municipal Medical Center, New York, for treatment of sepsis. His family related a history of crops of boils that appeared approximately ten years ago. After draining a whitish material, there were residual nodules. Simultaneously, a "mossy appearance" of the skin occurred at the periphery of the nodules. There was no

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