To the Editor.—
Yet to be found is a completely safe and effective treatment for disseminated granuloma annulare, an often refractory dermatosis that is marring, if not disabling. Cryotherapy, locally applied steroids, diethylstilbestrol, and, most recently, chlorambucil1 have met with varying success. The favorable effect in certain granulomatous panniculitises of potassium iodide taken orally in a dosage of 500 to 900 mg/day reported by Schulz and Whiting2 prompted the following study.
Method and Materials.—
After obtaining informed consent, four adult patients (patients 1, 2, and 4 were women; patient 3 was a man) with biopsy-verified disseminated granuloma annulare began therapy of either a saturated solution of potassium iodide or a placebo (water) in a randomized, double-blind study, beginning with 3 drops three times a day with meals and increasing to a maximum dose of 1 mL/day, which is equivalent to approximately 900 mg of potassium iodide per day.
Giessel M, Graves K, Kalivas J. Treatment of Disseminated Granuloma Annulare With Potassium Iodide. Arch Dermatol. 1979;115(5):639-640. doi:10.1001/archderm.1979.04010050063038