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May 1979

Antitrypsin Deficiency vs Gianotti-Crosti Syndrome-Reply

Author Affiliations

Odense, Denmark

Arch Dermatol. 1979;115(5):640. doi:10.1001/archderm.1979.04010050064040

In Reply.—  We thank Dr Stoller for his interest in our article, but we disagree that our findings should be in good agreement with the Gianotti-Crosti syndrome (papular acrodermatitis of childhood). In our patient, now 4 years old, skin changes were registered shortly after birth and have persisted. The eruption is still papular at the extremities and scattered at the trunk, but poikiloderma-like in the face. We agree that in the Gianotti-Crosti syndrome the eruption has roughly the same morphology, but it fades in a few weeks. Furthermore, the disease is separated from other papular eruptions of the extremities in childhood by always being associated with acute hepatitis, with hepatitis B antigen in the serum.1,2 As mentioned in our article, hepatitisassociated antigen was not found in our patient. In the Gianotti-Crosti syndrome, an infiltration, mostly perivascular, with lymphocytes and histiocytes is found in the upper part of the dermis,

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