A dramatic resolution of yellow nail deformity occurred in a 66-year-old man shortly after the removal of a carcinoma of the larynx. Seventeen months later, a productive cough developed and radiologic evidence of bronchiectasis was found. There was no evidence of lymphedema, pleural effusion, sinusitis, or immunologic abnormalities. At least three other patients with a variant of yellow nail syndrome have died of malignancy. Therefore, the resolution of the nail deformity following laryngectomy may not be fortuitous.
(Arch Dermatol 115:734-735, 1979)
Guin JD, Elleman JH. Yellow Nail SyndromePossible Association With Malignancy. Arch Dermatol. 1979;115(6):734-735. doi:10.1001/archderm.1979.04010060042027