An aged man with a large scaly plaque over the left buttock was successfully treated by local heat therapy using an electric bed-warmer with a surface temperature of 46 °C. Clinically, the lesion involuted completely after two months of treatment. This was concomitantly confirmed by histopathological and mycological studies of biopsy specimens obtained from the lesion at an interval of several weeks. The isolated fungus strain of Fonsecaea pedrosoi could grow at 37 °C on Sabouraud's dextrose agar, but was totally eradicated 24 hours after the culture was incubated at 46 °C. We consider that local heat therapy carried out under strict supervision is a quite effective treatment for chromomycosis. Moreover, it can be performed safely and without much discomfort to patients, and can yield satisfactory results in a relatively short time.
(Arch Dermatol 115:740-741, 1979)
Tagami H, Ohi M, Aoshima T, Moriguchi M, Suzuki N, Yamada M. Topical Heat Therapy for Cutaneous Chromomycosis. Arch Dermatol. 1979;115(6):740-741. doi:10.1001/archderm.1979.04010060048030