A 62-year-old woman with metastatic gastric carcinoma was treated with fluorouracil for her malignant neoplasm. Nail plate-nail bed separation was noted in the fingers and toes after two months of weekly chemotherapy and appeared to be caused by the fluorouracil.
(Arch Dermatol 115:860-861, 1979)
Katz ME, Hansen TW. Nail Plate-Nail Bed SeparationAn Unusual Side Effect of Systemic Fluorouracil Administration. Arch Dermatol. 1979;115(7):860-861. doi:10.1001/archderm.1979.04010070036018