Although neurofibromatosis and cutaneous melanoma are both diseases of neuroectodermal origin, reports of their association are rare. The case history of a patient with histologically documented neurofibromatosis and a nodular melanoma unrelated to a cafe-au-lait spot or congenital nevus is reported, and the literature reviewed. The appearance of only one patient with neurofibromatosis in a series of 900 patients with melanoma suggests that these diseases are probably not associated with greater frequency than that predicted by chance alone.
(Arch Dermatol 115:864-865, 1979)
Mastrangelo MJ, Goepp CE, Patel YA, Clark WH. Cutaneous Melanoma in a Patient With Neurofibromatosis. Arch Dermatol. 1979;115(7):864-865. doi:10.1001/archderm.1979.04010070040020