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August 1979

Recommended Treatment Schedules for Gonorrhea—1979

Arch Dermatol. 1979;115(8):993-995. doi:10.1001/archderm.1979.04010080057028

Physicians are cautioned to use no less than the recommended dosages of antibiotics.


Drug Regimens of Choice  The regimens of choice are as follows: Aqueous penicillin G procaine, 4.8 million units injected intramuscularly at two sites with 1.0 g of probenecid by mouth. Tetracycline hydrochloride,* 0.5 g by mouth four times a day for five days (total dosage, 10.0 g); other tetracyclines are not more effective than tetracycline hydrochloride; all tetracyclines are ineffective as a single-dose therapy. Ampicillin sodium, 3.5 g, or amoxicillin trihydrate, 3.0 g, both with 1 g of probenecid by mouth; evidence shows that these regimens are slightly less effective than the other recommended regimens.Patients who are allergic to the penicillins or probenecid should be treated with orally administered tetracycline as stated above. Patients who cannot tolerate tetracycline may be treated with spectinomycin hydrochloride, 2.0 g in one intramuscular

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