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Article
September 1979

Carcinoma in Atypical Ichthyosiform Dermatosis

Author Affiliations

San Francisco

Arch Dermatol. 1979;115(9):1034-1035. doi:10.1001/archderm.1979.04010090002006
Abstract

To the Editor.—  I read with great interest the article written by Cram and associates in the Archives (115:467-471, 1979), describing two children who shared a similar constellation of defects including an atypical ichthyosiform dermatosis, neurosensory deafness, vascularization of the corneas, anhidrosis, and abnormalities of the hair and nails. The authors also referred to 14 other patients described previously who displayed the same pattern of malformation.An isolated but important abnormality not mentioned in the article by Cram et al that occurred in one of those 14 individuals was reported by Baden and Alper.1 One of the two patients they described was noted at age 7 years to have a nodule of the tongue that, on biopsy, proved to be a squamous cell carcinoma; there was no evidence of either regional or distant metastases and the tumor was treated with irradiation. There has been no recurrence in eight years

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