Contact dermatitis developed in five patients due to Evans blue, an azo-type dye used to outline the lymphatics prior to the injection of a contrast medium in performing lymphangiography. A pathophysiologic mechanism for the development of dermatitis due to Evans blue is proposed.
(Arch Dermatol 115:1071-1073, 1979)
Guill MA, Odom RB. Evans Blue Dermatitis. Arch Dermatol. 1979;115(9):1071-1073. doi:10.1001/archderm.1979.04010090021016