Disseminated granuloma annulare (DGA) is a frequently severe chronic and disfiguring disease that is resistant to conventional methods of therapy. In a patient with DGA, low-dose chlorambucil therapy (2 mg three times daily, orally administered) resulted in dramatic and rapid clearing of all lesions in a short period of time. To my knowledge, this is the fourth case reported in which this therapeutic modality was used.
(Arch Dermatol 115:1212-1213, 1979)
Rudolph RI. Disseminated Granuloma Annulare Treated With Low-Dose Chlorambucil. Arch Dermatol. 1979;115(10):1212-1213. doi:10.1001/archderm.1979.04010100032013