To the Editor.—
The association between eruptive seborrheic keratoses and internal malignancy has been reported before1 and given the name of Leser-Trélat sign.2 In previous reports the affected organs were as follows: adenocarcinoma of the stomach, four cases3; adenocarcinoma of the large intestine, four cases4; and adenocarcinoma of pancreas,3 breast,3 ovary,1 uterus,2 and prostate,5 one case each. One patient had a squamous cell carcinoma of the lung6 and one had Sézary syndrome.1 Most of the patients were well over the age of 50 years. The time of eruption was short (between one and seven months).
Report of a Case.—
A 62-year-old woman was hospitalized for paresthesia and progressive weakness of the legs. During the previous five months she had noted onset of a large number of skin lesions on the head and trunk. On examination, multiple seborrheic keratoses were
Diaz EG, Leviatan A, Okon E. Renal Adenocarcinoma and Meningioma. Arch Dermatol. 1979;115(11):1286. doi:10.1001/archderm.1979.04010110002004