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November 1979

Management of Necrotizing Vasculitis With ColchicineImprovement in Patients With Cutaneous Lesions and Behçet's Syndrome

Author Affiliations

From the Division of Dermatology, University Hospitals of Cleveland.

Arch Dermatol. 1979;115(11):1303-1306. doi:10.1001/archderm.1979.04010110009014

Six patients with necrotizing vasculitis were treated with oral colchicine as part of an open study. Four patients with cutaneous vasculitis and normal levels of serum complement and one patient with vasculitis associated with Behçet's syndrome demonstrated clinical improvement while receiving colchicine. One patient with cryoglobulinemia, hypocomplementemia, and cutaneous vasculitis showed no response to colchicine therapy. In three patients, clinical improvement persisted after its withdrawal. Colchicine may be effective in controlling cutaneous necrotizing vasculitis and Behçet's syndrome through its effect on polymorphonuclear leukocyte function.

(Arch Dermatol 115:1303-1306, 1979)