Four patients with systemic lupus erythematosus (SLE) had a vesicobullous eruption that histologically resembled dermatitis herpetiformis. Immunofluorescence microscopy patterns in the skin studied in three patients, however, were characteristic of SLE. Treatment of the underlying collagen-vascular disease improved the eruption, while recurrence coincided with exacerbation of the systemic disease. This distinctive lesion is an important parameter of SLE activity.
(Arch Dermatol 115:1427-1428, 1979)
Penneys NS, Wiley HE. Herpetiform Blisters in Systemic Lupus Erythematosus. Arch Dermatol. 1979;115(12):1427-1428. doi:10.1001/archderm.1979.04010120025011