Benign dermatologic conditions, including sarcoidosis, erythema multiforme, urticaria, erythema nodosum, and others, have developed at the sites of vaccination.1 Scars from burns, x-rays, lupus vulgaris, lupus erythematosus, and chronic osteomyelitis are susceptible to cancerous change.2 The development of malignancy in vaccination scars is also a well-recognized event, with at least five different tumors having been described in vaccination sites: basal cell carcinoma, malignant melanoma, squamous cell carcinoma, fibrosarcoma, and dermatofibrosarcoma protuberans. We describe a patient in whom dermatofibrosarcoma protuberans developed at the site of multiple immunizations.
Report of a Case
A 33-year-old man had a rapidly growing mass in the deltoid region of his left arm. He had had multiple immunizations for plague, yellow fever, and tetanus at that site in 1965 at the time of his armed forces induction physical examination. His records were lost and he was subjected to the same injections into the same area
Morman MR, Lin R, Petrozzi JW. Dermatofibrosarcoma Protuberans Arising in a Site of Multiple Immunizations. Arch Dermatol. 1979;115(12):1453. doi:10.1001/archderm.1979.04010120049022