To the Editor.—
Concerning the article by Hashimoto and co-workers,1 we report here two cases of bullous pemphigoid in two brothers; the second case occurring only a few months after the first.
Report of Cases.—
A 90-year-old man had a pruritic rash on the dorsa of the hands followed later by a bullous eruption at the same sites and on the proximal portions of the limbs.His brother, aged 77 years, was affected a couple of months later by pruriginous, erythemato-edematous plaques, which later became bullous and were located on the dorsa of the hands and forearms.The histologic findings and direct and indirect immunofluorescence microscopy results confirmed the diagnosis of bullous pemphigoid.The HLA phenotyping disclosed four common loci in the brothers, HLA-A2, HLA-A11, HLA-Bw15, and HLA-Bw35.
No familial form of bullous pemphigoid seems to be mentioned in the literature. However, François et al2 described the
Civatte J, Belaich S, Morel P, Perron J, Jeanmougin M. Familial Bullous Pemphigoid. Arch Dermatol. 1980;116(2):157-158. doi:10.1001/archderm.1980.01640260033003