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Article
February 1980

Treating Keloids by Surgery and Methotrexate

Author Affiliations

Aba, Nigeria

Arch Dermatol. 1980;116(2):158. doi:10.1001/archderm.1980.01640260034004
Abstract

To the Editor.—  There are approved and speculative methods of treating keloids. Radiotherapy or injectable steroids, preferably in combination with surgery, are probably the two methods most commonly used. A new method of treating keloids involves surgery combined with methotrexate therapy.

Patients and Methods.—  After screening patients who had keloids for conditions that would preclude surgery and/or methotrexate chemotherapy, qualified patients began receiving oral or intramuscular methotrexate therapy (15 to 20 mg every four days for one to two weeks before surgery). If the keloid was suppurative1 (Fig 1), the patient was placed on a regimen of heavy antibiotic and analgesic/ anti-inflammatory therapy for about one week before surgery. The operation was performed under local and "cocktail" (chlorpromazine hydrochloride and morphine) anesthesia. The keloid was removed in its entirety, exposing the subcutaneous tissue and the rim of normal skin that surrounded the keloid.1 Adequate preparations for control of bleeding

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