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Article
February 1980

Immunologic Evaluation in Mycosis FungoidesBefore and After PUVA Therapy

Author Affiliations

From the Department of Dermatology, Cleveland Clinic Foundation, Cleveland. Dr Roenigk is now at the Department of Dermatology, Northwestern University School of Medicine, Chicago.

Arch Dermatol. 1980;116(2):178-181. doi:10.1001/archderm.1980.01640260054013
Abstract

• Eight patients with mycosis fungoides (seven in plaque stage and one with tumors) were successfully treated with methoxsalen-ultraviolet-A (PUVA) photochemotherapy. A selective immunity evaluation had been carried out prior to starting treatment and was repeated seven to 33 months (mean, 22 months) later. The results of pre-PUVA and post-PUVA therapy evaluation were compared. The delayed hypersensitivity responses improved in all eight patients, and four patients who were anergic before treatment manifested a normal response after PUVA therapy. The T lymphocyte counts were reduced in four patients before PUVA therapy (mean ± SD, 66.72% ± 9.78%) and in seven patients after PUVA (mean ± SD, 54.43% ± 10.86%; P = .03). The results of mitogen stimulation studies with phytohemagglutinin, pokeweed mitogen, and concanavalin A were equivocal. The levels of serum immunoglobulins were not affected. One patient had a positive antinuclear factor test of low titer.

(Arch Dermatol 116:178-181, 1980)

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