Kyrle's disease is an uncommon dermatosis of hyperkeratotic papules, with a distinctive histologic picture characterized by the penetration of a keratotic plug into the dermis. We report a case of Kyrle's disease in association with type II hyperlipoproteinemia.
Report of a Case
A 51-year-old man with a family history of diabetes mellitus had a personal history of proven nondietary type IIb hyperlipoproteinemia characterized by elevated plasma cholesterol and triglyceride levels; he also had known coronary artery disease and a three-year history of asymptomatic papules on both legs.Physical examination disclosed multiple well-demarcated, flesh-colored papules, with a central keratin plug, over the knees, as well as tibial tuberosities (Fig 1). The diagnosis at the time of examination was Kyrle's disease.A skin biopsy specimen of a keratotic papule showed marked invagination of the epidermis, filled with parakeratotic stratum corneum; absence of the granular layer beneath the parakeratotic horn, with marked thinning
Tomecki KJ, Battaglini JW, Maize JC. Kyrle's Disease and Type II Hyperlipoproteinemia. Arch Dermatol. 1980;116(2):227-228. doi:10.1001/archderm.1980.01640260103028