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March 1980

Sarcoidosis Responding to Allopurinol

Author Affiliations


Arch Dermatol. 1980;116(3):273-274. doi:10.1001/archderm.1980.01640270033006

To the Editor.—  No uniformly accepted therapeutic agent for sarcoidosis exists, although corticosteroids, immunosuppressive agents, antimalarial agents and phenylbutazone have all been useful under certain circumstances. Prompted by a report noting improvement of cutaneous sarcoidosis in two patients with gout receiving treatment with allopurinol,1 I evaluated the efficacy of allopurinol in the treatment of cutaneous sarcoidosis in two patients without a history of hyperuricemia. Informed consent was obtained from both patients.

Report of Cases.—Case 1.—  A 43-year-old woman with a 25-year history of sarcoidosis (biopsy-proven, of skin and epiglottis) had exhibited disfiguring, intensely pruritic cutaneous plaques and papules involving her face, thorax, and upper extremities since the age of 18 years. There was a history of recurrent synovial effusions of both ankles for the past ten years. Chest roentgenogram had revealed bilateral hilar adenopathy. Laboratory evaluation results, including results of complete blood cell count (CBC)

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