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April 1980

Lymphocyte Cyclic Nucleotide and Prostaglandin Content in Psoriasis: A Preliminary Report

Author Affiliations

From the Endocrinology Laboratory (Dr Harpaz and Mr Muhammad) and the Departments of Internal Medicine (Dr Fink) and Dermatology (Dr Zuckerman), Central Emek Hospital, Afula, Israel.

Arch Dermatol. 1980;116(4):427-428. doi:10.1001/archderm.1980.01640280063020

† Lymphocytes from psoriatic patients were found to contain reduced levels of adenosine 3′:5′-cyclic phosphate, guanosine 5′-cyclic phosphoric acid, and prostaglandin E, as compared with lymphocytes from normal subjects. The difference in prostaglandin F levels between psoriatic and control subjects was not statistically significant. These results could point to an immunologic defect in the immune system in psoriasis.

(Arch Dermatol 116:427-428, 1980)