† Necrosis of the skin developed soon after the initiation of coumarin therapy in an elderly woman. Inadvertent rechallenge resulted in similar lesions. Coumarin necrosis is a poorly understood phenomenon unlikely to respond to therapy. Fortunately, its incidence is quite rare, considering the widespread use of this anticoagulant.
(Arch Dermatol 116:444-445, 1880)
Schleicher SM, Fricker MP. Coumarin Necrosis. Arch Dermatol. 1980;116(4):444-445. doi:10.1001/archderm.1980.01640280080026