• In previously sensitized volunteers, higher concentrations of 2,4-dinitrochlorobenzene were necessary to elicit positive patch test reactions on the sundamaged skin of the neck than on the protected skin of the upper part of the back. This difference was not found in subjects without evidence of sun damage, and there was no difference between sundamaged and nondamaged skin in response to a primary irritant. Responses to intradermally injected common antigens were also less intense in sun-damaged skin than in nonexposed skin. These findings suggest the existence of a local defect in cell-mediated immunity in skin altered by long-term sun exposure.
(Arch Dermatol 116:559-561, 1980)
O'Dell BL, Jessen RT, Becker LE, Jackson RT, Smith EB. Diminished Immune Response in Sun-Damaged Skin. Arch Dermatol. 1980;116(5):559-561. doi:10.1001/archderm.1980.01640290069015