• A patient with Waldenström's macroglobulinemia had firm, translucent papules and nodules on the extremities. Clinically, the skin lesions were suggestive of amyloidosis cutis. Histologically, a homogeneous eosinophilic material was observed in the upper dermis and encasing the hair follicles. Special histochemical stains, electron microscopy, and immunofluorescence microscopy identified the material as IgM.
(Arch Dermatol 116:575-577, 1980)
Hanke CW, Steck WD, Bergfeld WF, Valenzuela R, Weick JK, Young JR, Gross EG. Cutaneous Macroglobulinosis. Arch Dermatol. 1980;116(5):575-577. doi:10.1001/archderm.1980.01640290085021