• A 60-year-old woman with recurrent papular and vesiculobullous lesions of erythema elevatum diutinum responded to treatment with 100 mg of oral niacinamide three times a day and 250 mg of tetracycline hydrochloride four times a day. Prior therapy with 2.5 mg of dexamethasone daily and 1.0 g of erythromycin daily had been unsuccessful. After four weeks, tetracycline therapy was discontinued, and niacinamide alone sufficed to suppress the disorder. Recurrent lesions developed whenever niacinamide therapy was stopped.
(Arch Dermatol 116:693-695, 1980)
Kohler IK, Lorincz AL. Erythema Elevatum Diutinum Treated With Niacinamide and Tetracycline. Arch Dermatol. 1980;116(6):693-695. doi:10.1001/archderm.1980.01640300081025