• Leukoedema is a white or whitishgray edematous lesion of the buccal and labial oral mucosa. The lesions may be diffuse or patchy, and are usually asymptomatic. Leukoedema may be confused with leukoplakia, Darier's disease, white sponge nevus, pachyonychia congenita, or candidal infection. The condition is seen most frequently among black men. The histologic appearance simulates that of white sponge nevus. Symptomatic leukoedema seems to respond to topical application of tretinoin.
(Arch Dermatol 116:906-908, 1980)
Duncan SC, Su WPD. Leukoedema of the Oral MucosaPossibly an Acquired White Sponge Nevus. Arch Dermatol. 1980;116(8):906-908. doi:10.1001/archderm.1980.01640320056014