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August 1980

Acquired Ichthyosis With Systemic Lupus Erythematosus

Author Affiliations

From the Department of Medicine, Division of Dermatology, Duke Medical Center and the Veterans Administration Medical Center, Durham, NC.

Arch Dermatol. 1980;116(8):952-954. doi:10.1001/archderm.1980.01640320102024

The occurrence of acquired ichthyosis in adults with systemic disease has previously been reported in Hodgkin's disease,1,2 other lymphoreticular malignant neoplasms,3 multiple myeloma,3 Kaposi's sarcoma,4 carcinoma of the lung, breast, and cervix,5 leprosy,6 and sarcoidosis.7 It has also been reported in patients receiving triparanol therapy.8 To the best of our knowledge, however, the association of acquired ichthyosis with systemic lupus erythematosus (SLE) has not been described previously. Acquired ichthyosis developed in our patient as the only cutaneous manifestation of lupus, and the dermatosis followed a clinical course similar to that of the patient's underlying disease.

Report of a Case  A 26-year-old woman was admitted to the Durham (NC) Veterans Administration Hospital in July 1979 for reevaluation of renal disease caused by SLE. In June 1978, the patient had symptoms of malaise, recurrent fever, polyarthralgias, Raynaud's phenomenon, and pleurisy with cardiomegaly of three

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