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To the Editor.—
I have recently seen a patient who has been receiving griseofulvin therapy for 20 years. He began taking griseofulvin in 1959 for the treatment of bilateral tinea pedis of the toe webs. He has taken the medicine almost continuously since that time, prescribed by numerous nondermatologist physicians. There have been occasional lapses of a few days, but a return of pruritus always prompted him to resume treatment. In recent years, he has taken microsize griseofulvin (250 mg/day).The patient was a well-nourished, healthy 60-year-old man. Examination of his feet indicated normal skin and nails without evidence of dermatophytosis. Potassium hydroxide wet mounts of scrapings of the undersurface of the toe nails and of the skin of the toe webs were normal. A fungal culture was negative. Urinalysis indicated a normal color, clear appearance, pH of 6.5, and a specific gravity of 1.001. Microscopic examination of the centrifuged
Mackaman BJ. Twenty Years of Griseofulvin Therapy. Arch Dermatol. 1980;116(10):1100. doi:10.1001/archderm.1980.01640340010003