• A 51-year-old man with primary systemic amyloidosis initially manifested periorbital purpura; later, skin fragility and hemorrhagic bullae developed. The bullae healed with formation of milia. The bullae were shown by electron microscopy to result from breaks in the fragile dermal amyloid deposits well below the basal lamina.
(Arch Dermatol 115:1164-1168, 1980)
Bluhm JF, Johnson SC, Norback DH. Bullous AmyloidosisCase Report With Ultrastructural Studies. Arch Dermatol. 1980;116(10):1164-1168. doi:10.1001/archderm.1980.01640340074020