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October 1980

Bullous AmyloidosisCase Report With Ultrastructural Studies

Author Affiliations

From the Departments of Dermatology (Drs Bluhm and Johnson) and Pathology (Dr Norback), William S. Middleton Memorial Veterans Hospital, and the University of Wisconsin, Madison, Wis.

Arch Dermatol. 1980;116(10):1164-1168. doi:10.1001/archderm.1980.01640340074020

• A 51-year-old man with primary systemic amyloidosis initially manifested periorbital purpura; later, skin fragility and hemorrhagic bullae developed. The bullae healed with formation of milia. The bullae were shown by electron microscopy to result from breaks in the fragile dermal amyloid deposits well below the basal lamina.

(Arch Dermatol 115:1164-1168, 1980)