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October 1980

Pyodermite Végétante of HallopeauImmunofluorescence Studies Performed in an Early Disease Stage

Author Affiliations

From the Department of Dermatology, University of Amsterdam, Binnengasthuis. Dr Neumann is now with St Lambertus Ziekenhuis, Helmond, the Netherlands.

Arch Dermatol. 1980;116(10):1169-1171. doi:10.1001/archderm.1980.01640340079021

• A 50-year-old woman with autoimmune thyroiditis had an eruption resembling pyodermite végétante as described initially by Hallopeau. Direct immunofluorescence microscopy studies indicated deposition of IgG and C3 in the intercellular area of the epidermis. Circulating IgG antibodies to the intercellular areas of stratified epithelial tissue were demonstrable on indirect immunofluorescence microscopy. Treatment with prednisone and azathioprine resulted in the disappearance of vegetating lesions and in healing, with postinflammatory hyperpigmentation. Immunofluorescence microscopy studies, in an early stage of the disease, are of great value in the diagnosis of pyodermite végétante of Hallopeau. Our findings support the view that pyodermite végétante of Hallopeau belongs immunologically to the pemphigus group.

(Arch Dermatol 116:1169-1171, 1980)