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January 1981

Dapsone HypersensitivityThe Sulfone Syndrome Revisited

Author Affiliations

From the Division of Dermatology, Department of Medicine, University of Florida College of Medicine, Gainesville. Dr Tomecki is now with the Department of Dermatology, Cleveland Clinic Foundation.

Arch Dermatol. 1981;117(1):38-39. doi:10.1001/archderm.1981.01650010044023

• A hypersensitivity reaction to low-dose (50-mg), short-term daspone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this "sulfone syndrome," an uncommon, potentially serious, side effect of dapsone therapy.

(Arch Dermatol 117:38-39, 1981)