• A hypersensitivity reaction to low-dose (50-mg), short-term daspone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this "sulfone syndrome," an uncommon, potentially serious, side effect of dapsone therapy.
(Arch Dermatol 117:38-39, 1981)
Tomecki KJ, Catalano CJ. Dapsone HypersensitivityThe Sulfone Syndrome Revisited. Arch Dermatol. 1981;117(1):38-39. doi:10.1001/archderm.1981.01650010044023