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January 1981

Extramedullary Hemopoiesis of the Skin

Author Affiliations

From the Department of Pathology, Veterans Administration Medical Center, New Orleans.

Arch Dermatol. 1981;117(1):58-59. doi:10.1001/archderm.1981.01650010064030

The skin is a potential site for extramedullary hemopoiesis since hemopoiesis occurs in the skin in early embryonic life. However, a review of the English literature reveals only five reported cases of extramedullary hemopoiesis of the skin.1-4 All of these patients suffered from myelofibrosis. I report herein another case of myelofibrosis associated with papulonodular and plaque-like lesions of the skin that microscopically exhibited extramedullary hemopoiesis.

Report of a Case  A 64-year-old man with fever of unknown origin that had been present for 14 months was admitted to the Veterans Administration Medical Center, New Orleans, in March 1974.Physical examination showed a nontender, palpable liver, 5 cm below the right costal margin, and a palpable spleen, 3 cm below the left costal margin. There was no lymphadenopathy. Hematologic studies indicated the following values: hemoglobin, 9.1 g/ dL; hematocrit, 31.7%; RBCs, 3,900,000/cu mm; WBC, 8,300/cu mm; differential cell count, normal; and

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